Xenograft Models

Compound Testing Objectives

How does the test compound affect tumor growth?

Does the test compound inhibit tumor invasion or metastasis?

Localization of test compound in the tumor?

Define drug characteristics:

Bioavailability

Toxicity

Efficacy

Potency

Is the cell line tumorigenic?

Are there changes in gene expression upon treatment or gene manipulation?

How

How does the test compound affect tumor growth?

Does the test compound inhibit tumor invasion or metastasis?

Localization of test compound in the tumor?

Define drug characteristics:

Bioavailability

Toxicity

Efficacy

Potency

Is the cell line tumorigenic?

Are there changes in gene expression upon treatment or gene manipulation?

How does gene manipulation in a cell line tumor growth, invasiveness, and metastasis ?

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Drug Administration

Compound Testing Objectives

Route Of Dose

~Non-Invasive Intratracheal

~Intraperitoneal (IP)

~Intravenous (IV)

~Oral gavage (PO)

Subcutaneous (SQ)

~Intramuscular (IM)

~Intracranial (IC)

~Intratumoral (IT)

~Capsule

~Continuous infusion

~Dermal

~Dietary admixture

~Intradermal (ID)

~Intranasal (IN)

Frequency of Dose

Duration of Dose

Common aSSAY End Points

Compound Testing Objectives

Common aSSAY End Points

Estimated tumor volume

(L x W2 /2)

Mean/median time to specified tumor volume

Survival time to specified tumor volume

Tumor doubling time

Tumor growth inhibition (TGI)

Tumor growth delay (TGD)

Increased life span (ILS)

Tumor cell kill rate

Xenograft and Syngeneic Models

Compound Testing Objectives

Compound Testing Objectives

Compound Testing Objectives

Drug Administration

Compound Testing Objectives

Compound Testing Objectives

Common aSSAY End Points

Compound Testing Objectives

Common aSSAY End Points

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