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    • Home
    • Services
      • Support Options
      • OnRequest Support
      • In-Vitro
      • In-Vivo
      • Ex-Vivo
      • Histology
    • Company
      • Meet The Team
      • Values & Commitments
      • About US
      • Message from the CEO
      • Photo Gallery
    • Resources
      • FAQ's
      • What is a cell assay?
      • What is a kinase??
      • Kinase Figures
      • Epigenetic Assays
      • Migration assay
      • Kinase Assays
      • NanoBRET
      • Cell Lines Top 10 Cancer
    • Contact

  • Home
  • Services
    • Support Options
    • OnRequest Support
    • In-Vitro
    • In-Vivo
    • Ex-Vivo
    • Histology
  • Company
    • Meet The Team
    • Values & Commitments
    • About US
    • Message from the CEO
    • Photo Gallery
  • Resources
    • FAQ's
    • What is a cell assay?
    • What is a kinase??
    • Kinase Figures
    • Epigenetic Assays
    • Migration assay
    • Kinase Assays
    • NanoBRET
    • Cell Lines Top 10 Cancer
  • Contact

Epigenetic Assays

cell based epigenetic assay
invitro, in vitro, in-vitro

Epigenetics is the study of changes in gene activity that do not involve alterations to the genetic code but can still be passed on through cell division. These changes include epigenetic factors that modify the genome in two ways - DNA methylation and histone modification. Both of them affect gene transcription by turning genes on or off:  

  • DNA methylation attaches methyl groups to the backbone of the DNA in specific places which may physically impede the binding of transcriptional proteins to the gene. Methylated DNA may also be bound by proteins that recruit other histone modifying proteins, thereby forming compact, inactive chromatin. 
  • Histone modification occurs on the N-terminal tails of histones, changing how tightly or loosely they package DNA. If tightly wound, a gene may be hidden from transcriptional proteins, therefore un-accessible. If loosened, a gene that was formerly hidden may be turned on.

IN-VITRO

Functional Assays:


  • Testing the modulation of the histones including acetylation, methylation, and phosphorylation. 


Go To assays

Binding Affinity

Using Promega's NanoBRET technologies we can test the binding affinity and residence time of new epigenetic compounds in intact cells

Find out more

Protein:Protein Interaction

Testing the interaction of bromodomains with histones in intact cells based on Promega's NanoBRET Bromodomain/Histone Interaction Assay.

assay details
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