Epigenetics is the study of changes in gene activity that do not involve alterations to the genetic code but can still be passed on through cell division. These changes include epigenetic factors that modify the genome in two ways - DNA methylation and histone modification. Both of them affect gene transcription by turning genes on or off:
Using Promega's NanoBRET technologies we can test the binding affinity and residence time of new epigenetic compounds in intact cells
Testing the interaction of bromodomains with histones in intact cells based on Promega's NanoBRET Bromodomain/Histone Interaction Assay.
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